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Optical sensors and fiber-based lab technology can detect early-stage Alzheimer’s disease

Advanced Research in Photonics (2022). DOI: 10.1002/adpr.202200044″ width=”800″ height=”431″/>

a) 3D view of the nanofunctionalized D-shaped laboratory fiber sensor. b) Associated detection mechanism based on the evaluation of refractive index changes, by the interaction of evanescent waves, which occur at the surface of the fiber and are determined by the spectral shift of the LMR, which is generated by a thin film of metal oxide. Credit: Advanced Research in Photonics (2022). DOI: 10.1002/adpr.202200044

Currently, the only accurate diagnosis of Alzheimer’s disease is through post-mortem analyzes after a patient dies, but researchers have now developed a highly sensitive method to quantify levels of tau protein – a hallmark of Alzheimer’s disease. disease – in the cerebrospinal fluid surrounding the brain and spinal cord.

The method, which relies on optical sensors and what is called “lab-on-fiber” technology, is described in a study published in Advanced Research in Photonics and it can detect even mildly elevated levels of tau protein that can occur in the very early stages of Alzheimer’s disease.

“Lab-to-fiber technology has advanced in recent years, and its combination with functional nanoscale materials can be applied to small volume samples for highly sensitive detection of molecules at low levels, offering potential early detection and personalized medicine,” said lead author Francesco Chiavaioli, Ph.D., MEng, of the National Research Council of Italy.


A New Sensation in Sensing Technology


More information:
Francesco Chiavaioli et al, Ultra-sensitive detection of Tau protein as a biomarker of Alzheimer’s disease via microfluidic and nanofunctionalized fiber optic sensors, Advanced Research in Photonics (2022). DOI: 10.1002/adpr.202200044

Quote: Optical sensors and fiber-based lab technology can detect early-stage Alzheimer’s disease (2022, July 21) Retrieved July 22, 2022, from https://medicalxpress.com/news/2022-07-optical- sensors-lab-on-fiber-technology-alzheimer.html

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